Final answer:
Indirect sympathetic nervous system stimulation causes vasodilation in skeletal muscle during exercise via beta-2 receptors.
Step-by-step explanation:
Indirect sympathetic nervous system stimulation causes vasodilation in skeletal muscle during exercise via beta-2 receptors. The sympathetic system, when activated during exercise, leads to the release of adrenaline or noradrenaline, which bind to beta-2 receptors in the skeletal muscle blood vessels. This binding causes relaxation of the smooth muscle surrounding the blood vessels, leading to vasodilation and increased blood flow to the skeletal muscles.