Final answer:
A clinical manifestation of nephrogenic systemic fibrosis is hyperpigmentation of the skin.
Step-by-step explanation:
A clinical manifestation of nephrogenic systemic fibrosis is hyperpigmentation of the skin. Nephrogenic systemic fibrosis is a rare condition that primarily affects individuals with kidney disease. Other clinical manifestations of this condition include hypopigmented skin, skin lesions, nodules, loss of peripheral nerve function, and in severe cases, the loss of fingers, toes, and extremities.
Hyperpigmentation refers to the darkening of the skin due to an excess production of melanin, the pigment responsible for the color of the skin, hair, and eyes. This condition can affect people of all skin types and can be caused by various factors.