Question

Release of TNF-a & IL-1 within a local area leads to activation of endothelial cells:

A) True
B) False

Answer 1

True. The release of TNF-a and IL-1 within a local area leads to activation of endothelial cells.

Step-by-step explanation:

True. The release of TNF-a and IL-1 within a local area leads to activation of endothelial cells. These pro-inflammatory cytokines play important roles in the immune response, but when they circulate in larger amounts, they can lead to life-threatening conditions such as septic shock. IL-1 induces vasodilation and reduces the tight junctions between vascular endothelial cells, causing widespread edema.