Final answer:
Coronary artery disease is the single largest killer of Americans each year.
Step-by-step explanation:
The single largest killer of Americans each year in terms of cardiovascular disease is D. Coronary artery disease.
Coronary artery disease occurs when the arteries that supply the heart muscle with oxygen and nutrients become narrowed or blocked due to the buildup of plaque. This can lead to heart attacks or other complications.
Coronary artery disease is often caused by risk factors such as high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol consumption.