Final answer:
Localized pain and tenderness in the lower right quadrant associated with acute appendicitis is caused by inflammation and infection of the appendix.
Step-by-step explanation:
With acute appendicitis, localized pain and tenderness in the lower right quadrant results from inflammation and infection of the appendix.
The appendix is a small, blind-end tube that can become infected due to the presence of indigestible material and bacteria. The infection can cause the appendix to burst, leading to the spread of infection in the abdominal cavity.
If a doctor suspects appendicitis, they may recommend surgical removal of the appendix to treat the infection.