Final answer:
Many of the clinical manifestations of systemic lupus erythematosus (SLE) are a consequence of tissue damage mediated by immune complexes.
Step-by-step explanation:
Many of the clinical manifestations of systemic lupus erythematosus (SLE) are a consequence of tissue damage mediated by immune complexes. Autoantibodies directed against nuclear and cytoplasmic proteins form immune complexes that deposit in tissues. Phagocytic cells and complement activation then cause tissue damage and inflammation.