Final answer:
Lipids are the most hydrophobic macromolecules as they have a predominantly nonpolar structure that does not mix well with water.
Step-by-step explanation:
Out of the macromolecules listed, lipids are the most hydrophobic. This is because they have a predominantly nonpolar structure, consisting of long chains of hydrocarbons that do not mix well with water. For example, fats and oils, which are types of lipids, are known for being hydrophobic as they are comprised of fatty acids and glycerol. Proteins, carbohydrates, and nucleic acids, on the other hand, have more polar or charged components that allow them to interact more with water, making them less hydrophobic in comparison.