Final answer:
The English colonies in the 1600s were primarily focused on agriculture and setting up family farms, while the French colonies were trade-oriented, specifically in the fur trade. This represents a significant difference in settlement patterns between the two.
Step-by-step explanation:
The major difference in settlement patterns between French and English colonies in the 1600s is that the English colonies were mainly agricultural, setting up family farms and growing cash crops like tobacco, especially in the South. In contrast, the French colonies centered around trade, particularly the fur trade with Native Americans, due to the shorter growing season in the regions they settled, such as around the St. Lawrence River and Hudson Bay. While the French relied heavily on alliances with Native peoples, establishing a network of trading posts and intermarrying with the native population (leading to the métis community), the English colonies often had more autonomous local governance and were more directly involved in farming and settling the land.