Final answer:
Granulomatosis with polyangiitis classically presents as necrotizing vasculitis involving the respiratory tracts, and while it may affect the kidneys, it is known for the combination of granuloma formation and vasculitis.
Step-by-step explanation:
Granulomatosis with polyangiitis (GPA), classically presents as C) Necrotizing vasculitis involving the upper and lower respiratory tracts. GPA, formerly known as Wegener's granulomatosis, is an autoimmune disease characterized by granuloma formation and vasculitis, which can lead to various symptoms and complications. This condition commonly affects the respiratory system, but it can also involve the kidneys leading to glomerulonephritis, which contributes to the complexity of the disease. Unlike some other conditions that lead to chronic renal failure or myocardial infarction, GPA is more distinct due to its combination of granuloma formation and vasculitis.