Final answer:
The most costly per unit element of the promotion mix involving direct interaction and flexibility is Personal selling.
Step-by-step explanation:
The element of the promotion mix that involves direct interaction, is most flexible and considered most costly per unit is C) Personal selling. Personal selling is characterized by one-on-one interaction between a sales representative and a potential customer. This method allows for detailed communication and tailored presentations to the client's needs, making it a highly effective form of promotion. However, due to its personalized nature, it requires significant investment in human resources, making it the most expensive on a per-unit or per-contact basis compared to other promotion mix elements such as advertising, public relations, and sales promotion.