Final answer:
Immunohistochemistry is the least desirable strategy for leukocyte evaluation and differentiation compared to manual blood smear review, automated hematology analyzers, and flow cytometry, due to its common use in solid tissue assessment rather than for blood samples.
Step-by-step explanation:
Among the various strategies for conducting leukocyte evaluation and differentiation, immunohistochemistry is the least desirable. Immunohistochemistry is a technique that involves staining tissues with antibodies to detect the presence of specific proteins. In the context of leukocyte evaluation, more suitable and commonly used methods include manual blood smear review, automated hematology analyzers, and flow cytometry. Manual blood smear review and use of automated hematology analyzers are direct methods for evaluating the morphological characteristics of leukocytes on a blood smear. Flow cytometry involves staining the cells with fluorescently labeled antibodies and passing them through a laser beam for analysis and cell counting, providing quantitative data about leukocyte subpopulations. Immunohistochemistry, however, is more commonly used for the assessment of solid tissues than for fluid samples like blood and is not well-suited for differentiating leukocytes in a blood sample.