Question

The following gives some pharmacokinetic parameters of a drug (P). Oral bioavailability 15% Protein binding 98% Renal clearance 5% Based on this data, which of the following statements is CORRECT?

A) The drug has a high oral bioavailability.

B) The drug is extensively cleared by the kidneys.

C) The majority of the drug is unbound in the plasma.

D) The drug is mainly excreted unchanged in the urine.

Answer 1

The correct statement based on the pharmacokinetic parameters is that the drug has high protein binding at 98%, which implies limited availability of unbound drug for effect or renal clearance.

Step-by-step explanation:

The correct statement concerning the pharmacokinetic parameters of the drug (P) is that it has a high protein binding of 98%. This is the only statement that can be deduced directly from the data provided. A high protein binding means that most of the drug is bound to plasma proteins, indicating that only a small fraction of the drug is unbound and free to exert an effect. The oral bioavailability of 15% is not considered high; it indicates that only a small percentage of the drug is absorbed into systemic circulation when taken orally. Furthermore, with a renal clearance of 5%, the drug is not extensively cleared by the kidneys, and it is not predominantly excreted unchanged in the urine. This is because a larger proportion of the drug is bound to the proteins, indicating limited free drug available for renal clearance.