Final answer:
Edvard Munch's most famous work of art is The Scream, symbolizing human emotion and angst.
Step-by-step explanation:
The Norwegian artist Edvard Munch is renowned for his iconic work of art titled The Scream. This highly recognized piece, completed in 1893, depicts a figure standing on a bridge, overcome with emotion and letting out a piercing scream. Characterized by its vivid colors and swirling background, The Scream has become a symbol of human anxiety and existential dread. Massacre of the Innocents and Dogs Playing Poker are works created by different artists and are not associated with Munch's body of work.