Final answer:
Signs of opioid intoxication include miosis, nausea, and possible seizures, while withdrawal symptoms mimic the flu, with vomiting and muscle aches; methadone can treat withdrawal.
Step-by-step explanation:
Common signs of opioid intoxication include miosis (pinpoint pupils), blurred or dim vision, headache, nausea, vomiting, diarrhea, excessive sweating, muscle twitching, difficulty breathing, and in severe cases, seizures or unconsciousness. On the other hand, symptoms of opioid withdrawal can resemble a severe case of the flu and may include vomiting, diarrhea, muscle aches, fever, and increased pain sensitivity.
Withdrawal is often treated with methadone or buprenorphine to alleviate symptoms, as these medications can provide stability without the high levels of euphoria associated with other opioids.