Final answer:
The provided reference materials do not explicitly state the positions in the antigen-binding groove of HLA-DQ2 that have high affinity for negatively charged residues; therefore, an immunology or molecular biology resource is needed to answer this question.
Step-by-step explanation:
The positions of the antigen-binding groove in HLA-DQ2 that have a high affinity for negatively charged residues are not explicitly stated in the provided reference information. The reference materials discuss various facets of molecular interactions involving amino acids, peptides, and RNA, including discussions of hypervariable regions, peptide binding interactions, and docking studies. However, they do not provide direct information concerning HLA-DQ2 and its affinity for specific residues. To answer questions about the specific binding positions in the context of HLA-DQ2, information from an immunology or molecular biology resource that focuses on the structure of HLA-DQ2 and its interactions with peptides would be required.