Question

Which consequence of mutations is most likely to cause an increase cancer risk?

a. Truncation of the Abi gene catalytic domain.
b. Amplification of the Abl gene alone.
C. Translocation that places the Ber gene under a highly-active promoter.
d. Amplification of the immunoglobulin genes

Answer 1

The translocation of a gene, such as the Ber gene, under a highly-active promoter is most likely to increase the risk of cancer due to its effects on transcriptional control and gene expression, which can lead to unregulated cell growth and division.

Step-by-step explanation:

The consequence of mutations most likely to cause an increase in cancer risk is c. Translocation that places the Ber gene under a highly-active promoter.

This type of genetic alteration is related to mutations affecting transcriptional control and gene expression, leading to unregulated cell growth and division. One example of the consequences of translocation is the Philadelphia chromosome, which results in the production of the BCR-abl fusion protein, an oncogenic tyrosine kinase that is associated with chronic myelogenous leukemia. Additionally, the malfunctioning of critical proteins such as p53 due to mutations can lead to unregulated proliferation and suppression of apoptosis, hence significantly increasing the risk of cancer development.