Question

The transactivation domain of coactivators promotes the activation of RNA polymerase, often by interacting with

a) DNA sequences
b) Other coactivators
c) Silencing domains
d) RNA molecules

Answer 1

The transactivation domain of coactivators activates RNA polymerase by interacting with other transcription factors, which in turn facilitates the binding of RNA polymerase II to the promoter region of the gene.

Step-by-step explanation:

The transactivation domain of coactivators promotes the activation of RNA polymerase, often by interacting with other regulatory proteins or transcription factors. These coactivators enhance the transcription process by facilitating the bending of DNA. This conformational change allows regulatory proteins, such as activators, to interact with enhancers and with other components of the transcription initiation complex, including RNA polymerase II. Coactivators do not directly interact with DNA sequences, RNA molecules, or silencing domains in this context, but rather with other proteins that regulate gene expression.