Final answer:
The inactivation of voltage-gated Na+ channels during nerve conduction is triggered by depolarization of the membrane.
Step-by-step explanation:
The inactivation of voltage-gated Na+ channels during nerve conduction is triggered by depolarization of the membrane. When a neuron is depolarized to at least the threshold of excitation, an action potential is fired. During repolarization, the inactivation gate of the voltage-gated Na+ channel closes, preventing any further influx of Na+ ions.