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The two TCAs with the lowest anticholinergic activity are

User Anirudh
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Final answer:

Nortriptyline and Desipramine are the two TCAs with the lowest anticholinergic activity.

Step-by-step explanation:

The two TCAs (Tricyclic Antidepressants) with the lowest anticholinergic activity are Nortriptyline and Desipramine.

User Kostek Poland
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