Question

Corticobasal degeneration and progressive supranuclear palsy are parkinsonian variants or Parkinson plus syndromes characterized by the accumulation of _______________

Answer 1

Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of Lewy bodies and the loss of dopaminergic neurons in the substantia nigra. The disease leads to symptoms like tremors, slowed movement, and balance problems. Glutamate excitotoxicity is also implicated in PD pathology.

Step-by-step explanation:

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the accumulation of cytoplasmic protein aggregates called Lewy bodies and the loss of dopaminergic neurons in the substantia nigra. These neurons help control muscle movement, and their degeneration leads to symptoms such as resting tremors, slowed movement, difficulty with movement, and balance problems. Glutamate excitotoxicity is also believed to play a role in PD pathology, contributing to the neurodegenerative processes.