Final answer:
The significant amount of blood loss after a fracture of the shaft of the femur is usually 250 to 500 mL.
Step-by-step explanation:
The correct answer is B. 250 to 500 mL .
When a fracture occurs in the shaft of the femur, there is often a significant amount of blood loss. This is because the fracture can cause damage to blood vessels in the periosteum, osteons, and medullary cavity of the bone, which results in bleeding. The amount of blood loss can range from 250 to 500 mL.