Final answer:
Inherited causes of indirect hyperbilirubinemia include Gilbert's syndrome, due to reduced UDP-glucuronyl transferase enzyme activity, and Crigler-Najjar syndrome, characterized by the absence of this enzyme, both leading to elevated unconjugated bilirubin.
Step-by-step explanation:
Two random inherited causes of indirect hyperbilirubinemia include conditions like Gilbert's syndrome and Crigler-Najjar syndrome. Gilbert's syndrome results from a defect in the uptake of bilirubin by the liver, which is attributed to reduced activity of an enzyme known as UDP-glucuronyl transferase. In contrast, Crigler-Najjar syndrome is characterized by the absence of this enzyme in the liver cells altogether, leading to elevated serum bilirubin levels and, in severe cases, can lead to significant neurological damage.
These inherited conditions affect the liver's ability to process bilirubin, leading to an accumulation of unconjugated bilirubin in the blood. This can result in jaundice, where the skin and whites of the eyes take on a yellowish hue due to the high levels of bilirubin.