Final answer:
The Indian Removal Act signed by President Andrew Jackson in 1830 forced the removal of native peoples from their land and led to the Trail of Tears.
Step-by-step explanation:
The act signed by President Andrew Jackson in 1830 that forced the removal of native peoples from their land was the Indian Removal Act. This act led to the infamous Trail of Tears, which was the forced relocation of Native Americans from their ancestral homelands in the Southeastern United States to designated Indian Territory in the West.
Many Native Americans suffered from exposure, disease, and starvation during this journey, resulting in the deaths of thousands.