Final answer:
In the book 'Resistance,' the supreme act of defiance committed by the Resistance after day 1 of the Warsaw Ghetto attack was the destruction of the Great Synagogue.
Step-by-step explanation:
In the book Resistance, the supreme act of defiance committed by the Resistance after day 1 of the Warsaw Ghetto attack was (a) They blew up the Great Synagogue. This act occurred on May 16, 1943, and symbolized the tragic end of the organized Jewish resistance in the Warsaw Ghetto. Despite their courageous efforts, the uprising ultimately did not stop the atrocities of the Holocaust, but it remains a powerful symbol of resistance and the human spirit's capacity to fight against oppression.