Final answer:
The lambda light chain of Immunoglobulin is coded by chromosome 22, and the unique sequencing of light chains is a result of genetic recombination and splicing.
Step-by-step explanation:
The chromosome that codes for the lambda light chain of the Immunoglobulin (Ig) is chromosome 22. In humans, immunoglobulin molecules have light chains that can be either kappa (k) or lambda (λ). Each B cell typically has a unique lambda light chain due to the recombination process involving DNA recombinase, which shuffles variable (V) and joining (J) segments to create a diverse array of antibodies. It is crucial to remember that light chains are part of the immune response, and their variability allows the immune system to recognize and bind to a wide range of antigens.
A germ-line B cell uses DNA recombinase to randomly excise most V and J segments from the light chain gene, and only one V segment is spliced to one J segment. During mRNA splicing, further rearrangement occurs, allowing for the creation of a unique variable region in each antibody. This complex process of recombination and splicing can result in over 106 possible VJ combinations, contributing to the vast diversity of the human immune response.