Final answer:
In 'Of Mice and Men', Crooks is the stable hand who is isolated by the other workers, reflecting the social issues of racial discrimination during the Great Depression.
Step-by-step explanation:
The stable hand who is isolated by the other workers is C) Crooks. In John Steinbeck's novel, 'Of Mice and Men', Crooks is the African American stable hand who experiences social isolation due to his race. This character's situation mirrors the historical context of racial discrimination during the Great Depression era in which the story is set. Unlike the scenario with Barney and young Barney, who are under severe scrutiny for their work, Crooks is isolated more because of racial prejudice than his work performance.