Question

Optimal Naïve CD8+ T cell activation involves 3 signals: Signal 3 =

a) Antigen recognition
b) Co-stimulatory molecules
c) Cytokine release
d) T cell receptor binding

Answer 1

Signal 3 in optimal Naïve CD8+ T cell activation involves a) antigen recognition, b) co-stimulatory molecules, and c) cytokine release.

Step-by-step explanation:

Signal 3 in optimal Naïve CD8+ T cell activation involves three components:

1. Antigen recognition: This refers to the binding of the T cell receptor (TCR) to the specific antigen presented by the antigen-presenting cell (APC) through major histocompatibility complex (MHC) molecules.
2. Co-stimulatory molecules: These molecules, such as CD80 and CD86 on the APC, interact with CD28 on the T cell, providing the second signal for full activation.
3. Cytokine release: Cytokines, released by the APC or other cells in the immune system, provide the third signal for complete T cell activation.