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The "Mason-Dixon line" was first used in debates over this 1820 compromise, which dealt with the issue of slavery. What is it?

a) Missouri Compromise
b) Compromise of 1850
c) Kansas-Nebraska Act
d) Fugitive Slave Act

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Final answer:

The "Mason-Dixon line" was first used in debates over the 1820 compromise, known as the Missouri Compromise, which dealt with the issue of slavery.

Step-by-step explanation:

The "Mason-Dixon line" was first used in debates over the 1820 compromise, which is known as the Missouri Compromise. This compromise dealt with the issue of slavery and established the boundary line between free and slave territories. Under this compromise, Missouri was admitted as a slave state and Maine as a free state, with the line drawn at 36°30' as the dividing line for future expansion of slavery.

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