Final answer:
Option B, "The weather, in fact, was quite nice today," uses punctuation correctly to set off words from the rest of the sentence.
Step-by-step explanation:
Option B, “The weather, in fact, was quite nice today,” uses punctuation correctly to set off words from the rest of the sentence. The comma before and after the phrase “in fact” acts as a pair of parentheses, indicating that the phrase is inessential to the sentence's meaning but provides additional information. This punctuation choice helps to separate the phrase from the main sentence.