Final answer:
HIV transmission across the blood-brain barrier most often occurs through infected monocytes.
Step-by-step explanation:
The transmission of HIV across the blood-brain barrier most often occurs through infected monocytes. Monocytes are a type of white blood cell that can be infected by the HIV virus. These infected monocytes can then cross the blood-brain barrier and introduce the virus into the brain. This mode of transmission is known as hematogenous spread.