Question

In which phase of wound healing is fibrin most involved?

Select one:
a. Second phase
b. All phases
c. First phase
d. Third phase

Answer 1

Fibrin is most involved in the first phase of wound healing, known as hemostasis, where it helps form a stable clot to stop bleeding and begin tissue repair.

Step-by-step explanation:

Fibrin plays a critical role in the wound healing process, particularly during the first phase, known as hemostasis. When the body sustains a skin injury, the immediate response is to stop the bleeding; this is where fibrin is most involved. The process of hemostasis involves three key steps:

1. Vascular spasm, which constricts blood flow to the area.
2. Formation of a platelet plug to temporarily seal breaks in the blood vessel.
3. Coagulation, where fibrinogen is converted into fibrin to strengthen the platelet plug with a more stable clot, facilitating the repair of the vessel wall and preventing further blood loss.

The synthesis of fibrin in blood clots can follow an intrinsic or extrinsic pathway, both converging into a common pathway essential for the clot's stability. The fibrin network not only traps blood cells, but also binds wound edges to initiate healing. As such, fibrin's most significant involvement is within the first phase of wound healing, making option c the correct choice.