Question

A 44-year-old G1P1 was placed on three months of a GnRH agonist in order to diminish the size of a 5 cm submucosal myoma and allow it to be accessible to a hysteroscopic removal. About two weeks prior to surgery, she was no longer having severe menorrhagia although the drug side effects were becoming incapacitating. During the pre-operative visit, she asks you if she could simply stop the GnRH agonist and wait to see if her symptoms eventually return. What can you inform her about the response of the fibroids after the cessation of GnRH agonist therapy?

A. Will not grow
B. Will resume their former growth potential
C. Become calcified
D. Will grow at a more rapid rate
E. Will re-grow but to only about half their original size

Answer 1

After the cessation of GnRH agonist therapy, the fibroids may resume their former growth potential due to the normalization of hormone levels.

Step-by-step explanation:

After the cessation of GnRH agonist therapy, the fibroids may resume their former growth potential. GnRH agonists work by suppressing the production of estrogen and progesterone, which are the hormones that stimulate fibroid growth. When the therapy is discontinued, the hormone levels return to normal, providing the opportunity for the fibroids to grow again.