Question

In addition to inhibiting the reabsorption of sodium and water in the loop of henle, what else is lost when taking loop diuretics?

Answer 1

Loop diuretics inhibit the reabsorption of sodium, water, and other electrolytes in the loop of Henle, leading to their excretion in the urine.

Step-by-step explanation:

Loop diuretics, such as furosemide, not only inhibit the reabsorption of sodium and water in the loop of Henle, but they also cause the loss of other electrolytes such as potassium, magnesium, and calcium.

This happens because loop diuretics act on a specific transporter called the Na-K-2Cl cotransporter, which is responsible for reabsorbing these electrolytes in the ascending limb of the loop of Henle.

By inhibiting this transporter, loop diuretics impair the reabsorption of these electrolytes, resulting in their excretion in the urine.