Final answer:
The question involves mathematics and pharmacokinetics, and the answer is 225 mg since no second dose has been taken and the first dose has not significantly cleared.
Step-by-step explanation:
In this scenario, we are dealing with a mathematics problem that requires an understanding of dosage and pharmacokinetics. Specifically, how the amount of a drug changes over time after administration, given that a dose is taken every 12 hours. Since no specific data about the drug's half-life or elimination rate is provided, we must assume the question is asking about the cumulative dose present 12 hours after the first dose has been taken. As such, after 12 hours, the patient will still have the initial full dose of 225 mg in their system, because a second dose has not yet been taken, and the first dose has not yet begun to clear significantly unless the half-life is less than 12 hours, which we aren't given information about.