Final answer:
Thermoreceptors fire when the temperature is above freezing point, within a comfortable range, and when the temperature is extremely hot.
Step-by-step explanation:
Thermoreceptors, which are responsible for detecting temperature, fire when the temperature is above freezing point, within a comfortable range, and when the temperature is extremely hot. These receptors are located in the dermis, skeletal muscles, liver, and hypothalamus. When the temperature changes, the receptors send signals to the brain, allowing us to perceive warmth or cold.