Final answer:
Crossing a female horse with a male donkey produces a mule, which is a strong and enduring hybrid animal but is typically sterile.
Step-by-step explanation:
The result of crossing a female horse with a male donkey is a mule. This is an example of a hybrid animal, and mules are known for their strength, endurance, and temperament, mixing the traits of their parents. Mules cannot reproduce because they are typically sterile due to the different number of chromosomes from the horse and the donkey.