Final answer:
In calculating the GFR results for women, the creatinine clearance is typically multiplied by 0.85. This correction accounts for biological differences between men and women, such as muscle mass, which affects creatinine production and clearance levels. Accurate measurement of GFR is crucial for detecting kidney disease and managing medication dosages. The correct answer is option 1) the same as for men.
Step-by-step explanation:
Understanding Glomerular Filtration Rate (GFR) in Women
The glomerular filtration rate (GFR) is an essential measure of kidney function and it represents the volume of filtrate formed by both kidneys per minute. Creatinine clearance is a practical method to estimate the GFR and is calculated using the concentration of creatinine in urine and plasma and the urine flow rate. To ensure an accurate comparison across individuals of different body sizes, the creatinine clearance is corrected for body surface area (BSA) and expressed in terms of ml/min/1.73 m². When calculating the GFR results for women, the creatinine clearance is usually multiplied by 0.85.
The normal reference range for creatinine clearance is 90-139 ml/min for men and 80-125 ml/min for women, which already suggests a difference based on biological sex. As such, routine calculations for GFR in women take this difference into account by applying the correction factor. The correction factor of 0.85 compensates for the typically lower muscle mass in women, which leads to lower creatinine production and subsequently different clearance levels.
It is important to measure GFR accurately, as it assists in the detection and monitoring of kidney disease and in determining the appropriate dosage of medications that are excreted via the kidneys. Individuals with a GFR of less than 60 mL/min/1.73 m² for 3 months are classified as having chronic kidney disease, and the correction for GFR calculation in women is a part of the overall approach to managing renal health.