Final answer:
Cell division and proliferation are not typical events of cell signaling but are secondary processes influenced by signaling pathways, particularly by growth factors.
Step-by-step explanation:
The typical event that is NOT associated with cell signaling is 4) Cell division and proliferation.
Cell signaling is a complex communication process that coordinates numerous cellular activities. It begins with the activation of cell surface receptors by external signaling molecules, known as ligands. These receptors are often linked to certain enzymes, such as tyrosine kinases, which are integral in the propagation of the signal. The external signal is transmitted through intracellular pathways, triggering a cascade of events within the cell, often involving the phosphorylation of proteins by kinases and the generation of second messengers, such as calcium ions, cAMP, or IP3. While cell signaling does play an essential role in controlling cell division and proliferation by the action of growth factors, it's a resultant effect rather than an inherent part of the signaling process. The actual phenomenon of cell division and the ensuing proliferation are complex physiological processes that are governed by the cell-cycle machinery, which is indirectly activated by signaling pathways. Once the signaling cascade has been completed, the cell may undergo various responses, including a change in metabolism, gene expression, or indeed proliferation, if the signals are growth factors.