Question

Aminoglycosides (Gentamycin and Tobramycin)

a) Cause hypokalemia
b) Are nephrotoxic
c) Increase blood glucose
d) Stimulate appetite

Answer 1

Aminoglycosides, such as Gentamycin and Tobramycin, are nephrotoxic, neurotoxic, and ototoxic. They bind to the 30S ribosomal subunit and impair proofreading, resulting in the production of faulty proteins. They do not cause hypokalemia, increase blood glucose, or stimulate appetite.

Step-by-step explanation:

Aminoglycosides, such as Gentamycin and Tobramycin, are nephrotoxic (damaging to the kidneys), neurotoxic (damaging to the nervous system), and ototoxic (damaging to the ears). These drugs bind to the 30S ribosomal subunit of bacterial ribosomes, impairing the proofreading ability of the ribosomal complex. This impairment causes mismatches between codons and anticodons, resulting in the production of faulty proteins. They do not cause hypokalemia, increase blood glucose, or stimulate appetite.