Final answer:
The nurse must prioritize cardiac function tests for a woman receiving high-dose doxorubicin (Adriamycin) chemotherapy due to the risk of cardiotoxicity.
Step-by-step explanation:
The most important assessment for the nurse to make when caring for a 52-year-old woman receiving high-dose doxorubicin (Adriamycin) is D) Cardiac function tests. Doxorubicin is a chemotherapy drug known to cause cardiotoxicity, which can lead to heart damage. Cardiac function tests, such as an electrocardiogram (ECG) and echocardiogram, can help monitor the patient's heart function and detect any cardiac complications.