Final answer:
Encouraging regular movement and repositioning is the best nursing intervention to help prevent skin breakdown in a client with impaired mobility.
Step-by-step explanation:
One of the best nursing interventions to help prevent skin breakdown in a client with impaired mobility is to encourage regular movement and repositioning. This helps to distribute pressure and reduce the risk of prolonged pressure on certain body parts. By changing positions frequently, blood flow is improved, reducing the risk of necrosis and skin breakdown.