Final answer:
The nurse should monitor for a transfusion reaction within the first 20 minutes of administration of the transfusion to a child with sickle cell disease
Step-by-step explanation:
The nurse is monitoring for a transfusion reaction and knows it is most likely to occur within the first 20 minutes of administration of the transfusion. During a transfusion, incompatible blood types can lead to a type II hypersensitivity reaction called hemolytic transfusion reaction (HTR). This occurs when antibodies in the recipient's plasma bind to and destroy the transfused red blood cells. Symptoms of a transfusion reaction can include fever, chills, pruritus, urticaria, dyspnea, hemoglobinuria, and hypotension.