Question

Which of the following is most closely associated with Idiopathic Hemochromatosis?

A. HFE gene mutation
B. Factor V Leiden mutation
C. Alpha-1 antitrypsin deficiency
D. Glucose-6-phosphate dehydrogenase deficiency

Answer 1

Idiopathic Hemochromatosis is most closely associated with the HFE gene mutation and is a hereditary disease causing iron accumulation in the body. So, the correct option is A. HFE gene mutation

Step-by-step explanation:

The condition most closely associated with Idiopathic Hemochromatosis is A. HFE gene mutation.

Hemochromatosis is a hereditary disease that causes the accumulation of iron in the body, which can lead to liver damage.

Idiopathic Hemochromatosis, also known as Hereditary Hemochromatosis, is primarily caused by a mutation in the HFE gene. This gene helps regulate the amount of iron absorbed from the diet, and mutations can lead to excessive iron absorption and deposition in various organs, which can cause damage over time.

Therefore, the correct option is A. HFE gene mutation

Answer 2

HFE gene mutation is most closely associated with Idiopathic Hemochromatosis. Option A is correct.

Step-by-step explanation:

Idiopathic Hemochromatosis is primarily associated with A. HFE gene mutation. This genetic condition results in excess absorption of iron from the diet, leading to iron overload in the body's tissues and organs.

The HFE gene mutation specifically affects the regulation of iron absorption in the small intestine. Mutations in this gene disrupt the normal control of iron levels, causing the body to absorb too much iron from the food consumed.

As a result of increased iron absorption, excess iron accumulates in various organs such as the liver, pancreas, heart, and joints. Over time, this iron overload can lead to tissue damage and dysfunction in these organs, contributing to the characteristic symptoms of hemochromatosis.

Early detection through genetic testing and subsequent management, including regular blood removal (phlebotomy) to reduce iron levels, is crucial in controlling the progression of the condition and preventing complications.

Option A is the right answer.