Final answer:
Leonardo da Vinci's legacy holds him in great regard due to his artistic mastery, scientific curiosity, diverse talents, and influence on future generations.
Step-by-step explanation:
Leonardo da Vinci is held in such great regard because of his artistic mastery and innovation, his scientific curiosity and groundbreaking discoveries, and his diverse range of talents and accomplishments. As a painter, da Vinci's works were revolutionary for their innovative techniques, detailed knowledge of anatomy, and use of the human form. In addition to his artistic achievements, da Vinci made significant contributions to various fields of science and engineering, including the design of flying machines, military tanks, and bridges. His influence on future generations of artists and scientists is undeniable, as his work continues to inspire and guide individuals in these fields. Therefore, the correct answer is E. All of the above.