Question

As part of an effort to breed the perfect family dog, a team of geneticists is interested in measuring the map distance between the mood gene (which determines happy versus sad) and the behavior gene (which determines obedient versus disobedient). After examining a large number of dog pedigrees, they have been able to find 60 dogs whose inheritance of these 2 genes from one of their parents can be identified as either recombinant or non-recombinant. Of these 60 dogs, 48 inherited a non-recombinant set of alleles while 12 inherited a recombinant set of alleles. What is the MaxLOD score?

Answer 1

As part of an effort to breed the perfect family dog, a team of geneticists is interested in measuring the map distance between the mood gene, the MaxLOD score in this case would be 0.699.

Step-by-step explanation:

The MaxLOD score (Maximum Likelihood of odds) is a statistical value used in genetics research to measure the likelihood of two genes being linked on a chromosome. In this case, the geneticists are trying to determine the map distance between the mood gene and the behavior gene in dogs. The MaxLOD score is calculated by comparing the observed number of recombinant dogs to the expected number based on the recombination frequency.

Given that 48 dogs inherited a non-recombinant set of alleles and 12 dogs inherited a recombinant set of alleles, we can calculate the recombination frequency using the formula: Recombination frequency = (number of recombinant dogs / total number of dogs) * 100.

Using the given information, the recombination frequency is calculated as (12 / 60) * 100 = 20%.

The MaxLOD score is the logarithm of the odds, which is the ratio of the likelihood of the two genes being linked versus unlinked.

Therefore, the MaxLOD score in this case would be log10(1/0.2) = 0.699.