Final answer:
The rash caused by smallpox first appears on the face, which is important information for healthcare professionals concerning bioterrorism and outbreak response.
Step-by-step explanation:
In developing an educational program about bioterrorism and smallpox, a nurse should include that the smallpox rash typically first appears on the face. Smallpox, which is believed to have originated in Northeast Africa around 30,000 years ago, presents with a rash that begins on the face and then spreads to other parts of the body. This differentiates it from other diseases such as chickenpox, which tends to have a rash concentrated more on the trunk and variola, whose vaccine is derived from cowpox virus. Bioterrorism concerns mandate that healthcare professionals remain knowledgeable about these distinctions to effectively recognize and respond to potential outbreaks