Question

During a typical infection, dendrite cells first encounter pathogen in ____ and then transport the pathogen to ___ where pathogen-derived peptide fragment are present to ____.

A. Secondary lymphoid tissue; infected tissue; T cells
B. Secondary lymphoid tissue; infected tissue; B cells
C. endocytic vesicles; cell surface; MHC molecules
D. infected tissues, secondary lymphoid tissue; T cells
E. infected tissues, secondary lymphoid tissue; B cells

Answer 1

Dendritic cells encounter pathogens in infected tissues, transport them to secondary lymphoid tissue, presenting to T cells to initiate an immune response.

Step-by-step explanation:

During a typical infection, dendritic cells first encounter pathogens in infected tissues, and then transport the pathogen to secondary lymphoid tissue where pathogen-derived peptide fragments are presented to T cells. This process is critical for initiating an appropriate immune response. Dendritic cells act as professional antigen-presenting cells (APCs) that phagocytose pathogens and present antigen fragments on their surface with major histocompatibility complex (MHC) class II molecules. This presentation of antigens is recognized by T cells, which then become activated to respond to the infection.