Final answer:
Syndicated shows may be less popular than network shows during certain key times, which can be a disadvantage for advertisers seeking to maximize exposure.
Step-by-step explanation:
A disadvantage associated with the use of syndicated shows for advertising is: E. their lack of popularity when compared to network shows in certain dayparts, such as daytime, early prime time, and late fringe. While cable and syndicated shows offer a variety of content and have the flexibility of on-demand viewing, they can sometimes lack the viewership and audience appeal that traditional network shows offer during prime viewing times, which is crucial for advertisers seeking maximum exposure for their products or services. Moreover, networks generally have more sophisticated data on viewers which allows for better targeted advertising compared to syndicate providers.