Question

Which eukaryotic DNA polymerase assembles the leading strand and most of the lagging strand fragments and is thought to be the primary replicative enzyme?

a. polymerase γ
b. polymerase δ
c. polymerase ε
d. polymerase β
e. polymerase α

Answer 1

DNA polymerase delta (pol δ) is the eukaryotic enzyme responsible for assembling the leading strand and most of the lagging strand during DNA replication.

Step-by-step explanation:

The eukaryotic DNA polymerase that assembles the leading strand and most of the lagging strand fragments and is thought to be the primary replicative enzyme is DNA polymerase delta (pol δ). This enzyme works in association with the protein proliferating cell nuclear antigen (PCNA) and is important for the high-fidelity replication of DNA. While the leading strand is continuously synthesized by DNA polymerase delta, the lagging strand is synthesized by DNA polymerase epsilon (pol ε) in the form of Okazaki fragments. These fragments are later joined together by DNA ligase after the RNA primers are replaced with DNA.

Therefore, the correct answer to the question is b. polymerase δ.