Final answer:
Geographic location is the factor that may significantly vary between the economic condition of a city, state, or region and the national economic condition.
Step-by-step explanation:
The factor that may significantly vary between the economic condition of a city, state, or region and the national economic condition is geographic location.
Countries have different geographic features such as coastlines, mountains, rivers, deserts, and rainforests, which create different opportunities for commerce, health, and the environment. These geographic differences can affect the economic condition of a specific area compared to the national economic condition.